Wheldon began his IndyCar racing in 2002. He was crowned champion in 2005 and won the Indy 500 in 2005 and 2011.
Milton Keynes born Wheldon has never really had the recognition he deserves back home. In terms of popularity he was huge in America. He would have groupies, paps and mad fans following him all over the country with fans flying in on the regular from all over the world to watch him race.
Lewis Hamilton, 2008 Formula 1 world champion, said: "This is a tragic loss at such a young age."
He added: "He was an extremely talented driver. As a British guy, who not only went over to the States but who twice won the Indy 500, he was an inspirational guy and someone that every racing driver looked up to with respect and admiration.
"My heart goes out to his family and friends during this extremely difficult time."
The accident at the Las Vegas track happened when a number of cars came into contact on turn two, sending several of them airborne, smashing into the outside wall and catch fence. The cars were travelling at speeds of over 200mph.
Wheldon was airlifted to the nearby hospital where his family met him at his bedside. His wife Susie and two sons were also there with him for his last moments of life.
Messages of support came from many other known faces around the world.
Formula 1 driver Jenson Button wrote on Twitter: "Just woken up to the most horrific news. Dan Wheldon RIP."
He tweeted: "I have so many good memories of racing with Dan in the early 90s, a true fighter. We've lost a legend in our sport but also a great guy."
Red Bull driver Mark Webber tweeted: "Rest in Peace Dan. I remember our early days in the UK 95/96.. Miss ya.."
Our condolences go out to the family and friends of a truly great man.
Rest In Peace Dan Wheldon.
Image via Wikipedia Image 1, Image 2